S100A9型
促炎细胞因子
S100A8型
炎症
吞噬细胞
糖基化
免疫学
生物
体外
受体
细胞生物学
免疫系统
生物化学
作者
Johannes Roth,Thomas Vogl,Clemens Sorg,Cord Sunderkötter
标识
DOI:10.1016/s1471-4906(03)00062-0
摘要
Three members of the S100 family of calcium-binding proteins comprise a new group of proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.
科研通智能强力驱动
Strongly Powered by AbleSci AI