扣带回前部
扣带皮质
神经科学
精神分裂症(面向对象编程)
心理学
固定(群体遗传学)
尼氏体
大脑皮层
皮质(解剖学)
认知
医学
病理
精神科
中枢神经系统
染色
环境卫生
人口
出处
期刊:Archives of General Psychiatry
[American Medical Association]
日期:1987-07-01
卷期号:44 (7): 608-608
被引量:269
标识
DOI:10.1001/archpsyc.1987.01800190024004
摘要
A series of computer-assisted stereomorphometric analyses of the spatial arrangements of neurons and glia in postmortem cerebral cortex specimens has been developed and applied to both control subjects and schizophrenic patients. The data suggest that the anterior cingulate cortex of schizophrenic patients may contain domains or aggregates of neurons, particularly in layer II, which are smaller in size and separated by wider distances than those observed in the control group. Verification of the inferences made from the computer-generated data has been obtained by direct microscopic visualization and measurement of neuronal aggregates of layer II in Nissl-stained cingulate specimens from the control and schizophrenic groups. Statistical correction of the data, using multivariate statistics, for effects of age, hypoxia, postmortem interval, fixation, and neuroleptic exposure does not eliminate the differences in size and separation of neuronal aggregates in layer II of schizophrenic patients. The possible relevance of these findings to our understanding of schizophrenic symptomatology is discussed.
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