Sickle Cell Anemia

Letters and Corrections1 July 1978Sickle Cell AnemiaSAMUEL CHARACHE, M.D.SAMUEL CHARACHE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-145_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The "natural history" of sickle cell anemia in Saudi Arabs (Ann Intern Med88:1-6, 1978) is certainly different from the disease as we see it in the United States but not as different as Table 2 in Perrine's paper would suggest. There is a paucity of good data, but 44% of all patients in Baltimore do not have ankle ulcers, 17% of all patients older than 5 years of age do not have hemiplegia, and 13% of all patients have not had osteomyelitis. The series quoted in Reference 12 probably includes patients with "tropical ankle ulcers," which...References1. SERJEANT G: The Clinical Features of Sickle Cell Disease. Amsterdam, North-Holland Publishing Co., 1974, pp. 121-129 Google Scholar2. REYNOLDS J: The Roentgenological Features of Sickle-Cell Disease and Related Hemoglobinopathies. Springfield, Illinois, Charles C Thomas, Publisher, 1965, p. 52 Google Scholar3. PORTNOYHERION BJ: Neurological manifestations in sickle-cell disease. With a review of the literature and emphasis on the prevalence of hemiplegia. Ann Intern Med 76:643-652, 1972 LinkGoogle Scholar4. BARRETT-CONNOR E: Bacterial infection and sickle cell anemia. An analysis of 250 infections in 166 patients and a review of the literature. Medicine (Baltimore) 50:97-U2, 1971 CrossrefGoogle Scholar5. PEMBREYWOODWEATHERALLPERRINE MWDR: Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia. Br J Haematol, 1978, in press CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAMUEL CHARACHE, M.D.Affiliations: The Johns Hopkins Medical Institutions Baltimore MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1978Volume 89, Issue 1Page: 145-145KeywordsAnemiaAnklesArabic peopleNatural history of diseaseOsteomyelitisSickle cell diseaseUlcers ePublished: 1 December 2008 Issue Published: 1 July 1978 PDF downloadLoading ...