神经发生
细胞生物学
生物
干细胞
长寿
氧化应激
神经科学
神经干细胞
炎症
功能(生物学)
细胞分化
老化
基因
免疫学
遗传学
内分泌学
作者
Sergiy Libert,David S. Cohen,Leonard Guarente
摘要
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
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