免疫学
自身免疫
免疫系统
免疫
基因沉默
树突状细胞
免疫
疾病
免疫疗法
医学
生物
生物化学
基因
病理
作者
Ralph M. Steinman,Jacques Banchereau
出处
期刊:Nature
[Springer Nature]
日期:2007-09-01
卷期号:449 (7161): 419-426
被引量:1926
摘要
Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with DC-targeted vaccines. During allergy, autoimmunity and transplant rejection, DCs instigate unwanted responses that cause disease, but, again, DCs can be harnessed to silence these conditions with novel therapies. Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy.
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