生物
细胞生物学
细胞粘附
细胞间粘附分子
细胞粘附分子
纤维蛋白原
ICAM-1
内皮
受体
可溶性细胞粘附分子
免疫球蛋白超家族
内皮干细胞
整合素
神经细胞粘附分子
细胞间粘附分子-1
免疫学
细胞
生物化学
体外
内分泌学
作者
Lucia R. Languino,Janet Plescia,Alain Duperray,Adrienne A. Brian,Edward F. Plow,John E. Geltosky,Dario C. Altieri
出处
期刊:Cell
[Elsevier]
日期:1993-07-01
卷期号:73 (7): 1423-1434
被引量:334
标识
DOI:10.1016/0092-8674(93)90367-y
摘要
Leukocyte traffic in immune-inflammatory responses requires regulated adhesion of leukocyte subsets to vascular endothelium. We show that fibrinogen or normal human plasma enhances by 2- to 5-fold the adhesion of cells of myeloid and lymphoid lineage to endothelium. This mechanism is mediated by fibrinogen binding to complementary membrane receptors on leukocytes and endothelial cells. Using an affinity chromatography purification strategy, genetically engineered transfectants, and direct binding studies to the isolated recombinant protein, we identified a novel hematopoietic fibrinogen receptor participating in this adhesion pathway as intercellular adhesion molecule 1 (ICAM-1). Accordingly, a new model can be proposed, in which fibrinogen binding to a variety of vascular cell receptors mediates a specific pathway of cell to cell adhesion by bridging together leukocytes and endothelial cells.
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