肌酸激酶
置信区间
接收机工作特性
医学
杜氏肌营养不良
肌营养不良
新生儿筛查
荟萃分析
样本量测定
内科学
儿科
统计
数学
作者
Kelli Carneiro de Freitas Nakata,Priscilla Perez da Silva Pereira,Bruno Salgado Riveros
标识
DOI:10.1016/j.clinbiochem.2021.09.010
摘要
to evaluate the accuracy of the creatine kinase test in neonatal screening for Duchenne Muscular Dystrophy.Investigations were carried out in six databases, gray literature and manual search. All studies and data extraction eligibility processes were carried out in paired mode. The methodological stringency of the studies was assessed using the modified QUADAS 2 tool. The performance measures of the test were calculated using the Meta-DiSc software, version 1.4.11 studies were included, with a total sample of 1,416,123 newborns. The positive likelihood ratio was more than 10 in these studies. On the other hand, the negative likelihood ratio was up to 0.2 in 9/10 studies; however, when considering the upper limit of the confidence interval, only 4/10 studies showed a negative likelihood ratio less than 0.2 and in 6/11 it was greater than 0.5. Specificity was close to 1 in studies. The sensitivity was equal to or greater than 0.81 in 10/11 studies; however, when considering the reliability's minimum interval limit, only 6/10 studies showed sensitivity equal to or greater than 0.7. Ten studies were summarized on a ROC curve indicating good performance (Area under the curve = 0.9980 and Q index = 0.9846).the creatine kinase test showed good accuracy in screening for cases of Duchenne Muscular Dystrophy and may be a useful alternative in the early diagnosis of the disease followed by confirmatory genetic testing.
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