增食欲素
上瘾
清醒
神经科学
心理学
睡眠(系统调用)
嗜睡症
奖励制度
食欲
食欲素-A
外侧下丘脑
医学
神经学
神经肽
内分泌学
内科学
脑电图
计算机科学
受体
操作系统
作者
Jacqueline B. Mehr,Michelle M. Bilotti,Morgan H. James
标识
DOI:10.1016/j.tins.2021.09.002
摘要
Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function.
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