自噬
粒体自噬
冲程(发动机)
神经科学
医学
内质网
机制(生物学)
缺血性中风
平衡
生物信息学
细胞生物学
生物
缺血
细胞凋亡
内科学
工程类
哲学
认识论
机械工程
生物化学
作者
Xiaoyu Wang,Yuanjian Fang,Qingxia Huang,Penglei Xu,Cameron Lenahan,Jianing Lu,Jingwei Zheng,Xiao Dong,Anwen Shao,Jianmin Zhang
标识
DOI:10.1016/j.expneurol.2021.113684
摘要
Stroke is a leading cause of mortality and morbidity worldwide. Understanding the underlying mechanisms is important for developing effective therapies for treating stroke. Autophagy is a self-eating cellular catabolic pathway, which plays a crucial homeostatic role in the regulation of cell survival. Increasing evidence shows that autophagy, observed in various cell types, plays a critical role in brain pathology after ischemic stroke. Therefore, the regulation of autophagy can be a potential target for ischemic stroke treatment. In the present review, we summarize the recent progress that research has made regarding autophagy and ischemic stroke, including common signaling pathways, the role of autophagic subtypes (e.g. mitophagy, pexophagy, aggrephagy, endoplasmic reticulum-phagy, and lipophagy) in ischemic stroke, as well as the current methods for autophagy detection and potential therapeutic strategy.
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