癌症手术
自体荧光
医学
光学成像
医学物理学
影像引导手术
癌症
计算机科学
外科
放射科
光学
荧光
物理
内科学
作者
Stijn Keereweer,Pieter B A A van Driel,T Snoeks,Jeroen D. F. Kerrebijn,Robert J. Baatenburg de Jong,Alexander L. Vahrmeijer,Henricus J. C. M. Sterenborg,Clemens W.G.M. Löwik
标识
DOI:10.1158/1078-0432.ccr-12-3598
摘要
Optical image-guided cancer surgery is a promising technique to adequately determine tumor margins by tumor-specific targeting, potentially resulting in complete resection of tumor tissue with improved survival. However, identification of the photons coming from the fluorescent contrast agent is complicated by autofluorescence, optical tissue properties, and accurate fluorescent targeting agents and imaging systems. All these factors have an important influence on the image that is presented to the surgeon. Considering the clinical consequences at stake, it is a prerequisite to answer the questions that are essential for the surgeon. What is optical image-guided surgery and how can it improve patient care? What should the oncologic surgeon know about the fundamental principles of optical imaging to understand which conclusions can be drawn from the images? And how do the limitations influence clinical decision making? This article discusses these questions and provides a clear overview of the basic principles and practical applications. Although there are limitations to the intrinsic capacity of the technique, when practical and technical surgical possibilities are considered, optical imaging can be a very powerful intraoperative tool in guiding the future oncologic surgeon toward radical resection and optimal clinical results.
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