化学
组合化学
联轴节(管道)
偶联反应
计算化学
催化作用
有机化学
机械工程
工程类
作者
Wenjun Tang,Nitinchandra D. Patel,Guangqing Xu,Xiaobing Xu,Jolaine Savoie,Shengli Ma,Ming‐Hong Hao,Santosh Keshipeddy,Andrew G. Capacci,Xudong Wei,Yongda Zhang,Joe Gao,Wenjie Li,Sonia Rodrı́guez,Bruce Z. Lu,Nathan K. Yee,Chris H. Senanayake
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-04-12
卷期号:14 (9): 2258-2261
被引量:155
摘要
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki–Miyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile derivatization for further synthetic applications. A computational study has revealed that a π–π interaction between the two coupling partners can enhance the enantioselectivity of the coupling reaction.
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