Effect of Jieduquyuziying Medicine on Glucocorticoid Receptor α in MRL/lpr Mice

Objective:To evaluate the effect of Jieduquyuziying medicine on glucocorticoid receptor α(GRα) in MRL/ lpr mice.Methods:Forty MRL/lpr mice were divided into four groups at randomly:the model group;the western medicine group;the Chinese medicine group;the integration of Chinese and western medicine group,ten Km mice as the control group.Western blot and flow cytometry were used to observe the expression of GRα protein and the binding power of GRα.Results:The expression of GRα protein in kidney and GRα expression and the binding power of GRα in splenic lymphocytes of the model group were lower then those in the control group(P 0.01) .There was no significantly difference in the western medicine group and the model ones.GRα expression and the binding power in the Chinese medicine group and the integration of Chinese and western medicine group were higher than those in the model group(P 0.05) ,while no significantly difference compared with the control group.Conclusion:The protein expression and the binding power of GRα could be upregulated by Jieduquyuziying medicine in MRL/lpr mice,while no significantly effect with prednisone.