Expression of β-catenin correlates with the genesis and prognosis of human colorectal cancer

Objective To investigate the expression of β-catenin and its clinical pathological correlations with human colorectal cancer.Methods A total of 100 colorectal cancer samples' β-catenin was detected by immunohistochemistry(SP).Results A reduced membranous expression rate of β-catenin was observed in 80.0% of the cases(80/100)along with a nuclear expression rate 26.0%(26/100).There was a significant difference in β-catenin expression between well-to-moderately and poorly differentiated colorectal cancer.Well-to-moderately differentiated colorectal cancer showed a reduced expression rate 70.0%(35/50),in contrast to 90.9%(45/50)in poorly differentiated tumors(P=0.012).Reduced β-catenin expression rate was 87.3%(48/55)in case with lymph node metastasis,in contrast to 71.1%(32/45)in cases without lymph node metastasis(P=0.044).Conclusion The reduced membranous expression of β-catenin is associated with poorly differentiated and lymph node positive human colorectal cancer.