代谢物
硫代苹果酸金钠
奥兰诺芬
医学
尿
金标准(测试)
金化合物
活性代谢物
药理学
色谱法
内科学
化学
组合化学
类风湿性关节炎
作者
R. C. Elder,Zheng Zhao,Yafei Zhang,John G. Dorsey,E V Hess,Katherine Tepperman
出处
期刊:PubMed
[National Institutes of Health]
日期:1993-02-01
卷期号:20 (2): 268-72
被引量:44
摘要
Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
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