Distribution and persistence of neutralizing antibody titer against human cytomegalovirus in plasma donors in Sichuan Province,China

Objective To analyze the distribution and persistence of neutralizing antibody titer against human cytomegalovirus(HCMV) in plasma donors in Sichuan Province,China.Methods A total of 2 002 serum samples of health plasma donors were collected from 8 plasma stations in Sichuan Province and determined for neutralizing antibody titer by developed method,based on which the samples from 44 donors were traced for one year,and those from one donor for 4 years.Results The neutralizing antibody titers against HCMV in plasma donors in Sichuan Province were mainly distributed in 1 ∶ 16 ～ 1 ∶ 64,while the positive rate(not less than 1 ∶ 8) was 98.35%,of which 8.04% were not less than 1 ∶ 192.The neutralizing antibody titers of 44 plasma donors were stable within the past one year.However,the neutralizing antibody titers of the donors traced for 4 years were maintained at high levels.Conclusion The natural infection rate of HCMV was high in plasma donors in Sichuan Province.The HCMV neutralizing antibody titers were high and persistent in partial donors.It provided a basis for preparation of HCMV-specific IgG.