Objective To study the antipyretic effects of ibuprofen suspension and mixed paracetamol suspension drops.Methods 230 children with fever symptoms were randomly divided into two groups:ibuprofen group(120 cases) and paracetamol group(110 cases).Ibuprofen group took ibuprofen suspension 7 mg/kg each time,paracetamol group took mixed paracetamol suspension drops 10~15 kg/kg each time.The changes of temperature were recorded after taking drugs 1~6 hours.Results The both antipyretic effects in 2 hours had no significant defference(P0.05).The antipyretic effects of ibuprofen in 3 hours was significantly better than that of paracetamol group.The temperature of paracetamol group went up in 4 hours.The antipyretic rate was 77.5%.The antipyretic effects of ibuprofen was still remained in 6 hours.Its antipyretic rate was 90%.Conclusion Ibuprofen suspension has better antipyretic effects and keep longer time.