This research aimed at setting up silica based DNA purification method to purify DNA from giant panda feces It is concluded that silica can bind bacterial genomic DNA at high concentration of KI and in neutral condition We use this condition to purify DNA by silica The result shows that we can purify bacterial genomic DNA by this method and purified DNA can be used to PCR reaction But classic organic solvent DNA purification method can not remove PCR inhibitors, which leads to false negative result