剂型
活性炭
淋巴
吸附
化学
药理学
医学
病理
有机化学
作者
Akeo Hagiwara,Ahn T,Taeko Ueda,A Iwamoto,Tsuyoshi Torii,Teisuke Takahashi
出处
期刊:PubMed
日期:1986-09-01
卷期号:6 (5): 1005-8
被引量:8
摘要
A new dosage form consisting of small activated carbon particles which adsorb Aclacinomycin A, Adriamycin, Mitomycin C or Pepleomycin was prepared in order to deliver larger amounts of anticancer agents to the lymph nodes through the high ability of lymphatics to adsorb particles. Animal experiments showed that: The LD50 values of the new dosage form were higher than those of the dosage in solution. The concentration of agents in lymph nodes was maintained at a higher level in the new dosage form than in solution form. Clinically 33% of lymphnodal metastatic lesions became degenerative or inflammatory after a single administration.
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