化学
区域选择性
差向异构体
烷基化
四级碳
手性助剂
组合化学
立体化学
有机化学
催化作用
对映选择合成
作者
Shuanglin Qin,Shuangwei Liu,Yuting Cao,Jiangnan Li,Chuanke Chong,Tongtong Liu,Yukun Luo,Jiyun Hu,Shende Jiang,Honggang Zhou,Guang Yang,Cheng Yang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-02-15
卷期号:20 (5): 1350-1354
被引量:10
标识
DOI:10.1021/acs.orglett.8b00105
摘要
This study developed a facile and efficient synthetic strategy to construct quaternary chiral centers at the α-position of imines and ketones. High regioselectivity and diastereoselectivity were achieved through the synergetic effect of electron-withdrawing directing groups and N-tert-butyl sulfinamide as chiral auxiliaries. Either of them could be removed under the optimized conditions without any epimerization.
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