纳米囊
壳聚糖
盐酸阿霉素
细胞毒性
化学
果胶
药物输送
聚电解质
纳米技术
体外
阿霉素
生物物理学
纳米颗粒
材料科学
生物化学
有机化学
聚合物
化疗
外科
生物
医学
作者
Ji Feng,Junjie Li,Zhihui Qin,Boguang Yang,Ershuai Zhang,Dianyu Dong,Jinmei Wang,Wen Yan,Liang Tian,Fanglian Yao
标识
DOI:10.1016/j.carbpol.2017.08.107
摘要
Multifunctional capsules have great applications in biomedical fields. In this study, novel polysaccharide-based nanocapsules were prepared via a layer-by-layer technique using silica as the templates. The shell was constructed based on the electrostatic interactions between pectin and chitosan. The pectin-chitosan nanocapsules ((Pec/Cs)3Pec) could keep good colloidal stability within 96h in PBS solution and 48h in BSA solution. Meanwhile, the nanocapsules exhibited a high drug loading and pH-sensitive release property for doxorubicin hydrochloride. Moreover, (Pec/Cs)3Pec nanocapsules had no cytotoxicity to both human hepatocellular carcinoma cells (HepG2 cells) and mouse fibroblast cells (L929 cells). More importantly, (Pec/Cs)3Pec nanocapsules could be more easily uptaken by HepG2 cells when compared with L929 cells. In vitro anticancer activity tests indicated the carriers could effectively kill HepG2 cells. Overall, (Pec/Cs)3Pec nanocapsules have great potential as a novel anticancer drug carrier as a result of their pH-sensitivity, good colloidal stability and anticancer activity.
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