抗真菌
抗真菌药
抗药性
背景(考古学)
抗真菌药
生物
多重耐药
光滑假丝酵母
酵母
微生物学
抗性(生态学)
计算生物学
遗传学
生态学
古生物学
作者
Florent Morio,Rasmus Krøger Hare,Patrice Le Pape,Maiken Cavling Arendrup
标识
DOI:10.1016/j.ijantimicag.2017.05.012
摘要
Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.
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