Changes of PC and AT-III in the patients with II diabetic nephropathy

Objective To investigate the changes of serum Protein C (PC) and Antithrombin Ⅲ (AT-Ⅲ) in the early or late stage of the patients with diabetic nephropathy (DN) and explore the effect of PC and AT-Ⅲ in etiopathology and progression of DN. Methods The serum samples were collected from 125 Ⅱ diabetes mellitus (DM) patients and 38 controls, and the DM group was divided into non-albuminuria group (UAE30mg/24h, 45 samples) and albuminuria group (UAE30mmg/24h, 80 samples). Then, the level of PC and the activity of AT-Ⅲ were detected, respectively. Results Compared with controls (102.3±17.3%), the level of PC in both non-albuminuria group and albuminuria group significantly increased (non-albuminuria group: 124.1±10.7%, p 0.05; albuminuria group: 171.5±36.5%, p 0.05). In addition, the level of PC in the albuminuria group was significantly higher than that in the non-albuminuria group (p0.05). Compared with controls (95.4±6.5%), the activityl of AT-Ⅲ in both non-albuminuria group and albuminuria group significantly decreased (non-albuminuria group:79.4±29.4%, p 0.05); albuminuria group: 40.6± 13.2%(p 0.05). In addition, the acticvity of AT-Ⅲ in the albuminuria group was significantly lower than that in the non-albuminuria group (p 0.05). Conclusions It is obvious that DM patients have coagulation disorder and the degree of the disorder relates with the development of DM. PC and AT-Ⅲ can be used in monitoring the progression of DN, especially in the early stage.