坦索罗辛
医学
泌尿科
安慰剂
输尿管
不利影响
安慰剂组
B组
外科
内科学
病理
替代医学
增生
作者
Alsayed Saad Abdelaziz,Yasser Badran,Ahmed Yousef Aboelsaad,H. El-Hilaly
标识
DOI:10.1016/j.afju.2016.02.006
摘要
Abstract Objectives To evaluate and compare the efficacy of tamsulosin (0.4 mg, once/day) and combinations of it with trospium (20 mg, twice/day) in the treatment of single small lower ureteral stones. Patients and methods A total of 126 patients presenting to urology outpatient clinics from July 2012 to May 2015, with a single 5–10 mm sized lower ureteral stone were randomly classified into two treatment groups. Patients in group A (n = 62) received an oral dose of 0.4 mg tamsulosin once daily and 20 mg trospium chloride twice daily. Patients in group B (n = 64) received 0.4 mg tamsulosin once daily and placebo twice daily. The spontaneous passage of stones, the stone expulsion time, and adverse effects were evaluated. Results There were no significant differences in baseline characteristic of the patients in both groups. Stone expulsion was observed in 47 patients (75.8%), and 58 (90.62%) in groups A and B respectively. The average time to expulsion was 11.65 ± 5.32 days in group A and 17.35 ± 6.21 days in group B. The spontaneous stone passage rate through the ureter was significantly higher and the stone expulsion time was faster in groups A than in group B (p Conclusions The combination of 0.4 mg tamsulosin and 40 mg trospium as MET for single lower ureteral stones
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