[The expression of MFAP5 in ovarian cancer and its effect on cancer cell proliferation, metastasis and drug resistance].

MFAP5 is highly expressed in ovarian cancer, especially in the stromal tissue of ovarian cancer, where the expression level is the highest. High expression of MFAP5 often indicates a poor prognosis for ovarian cancer patients. By reducing the expression of MFAP5 in CAFs, the supportive effect on the malignant biological behavior and drug resistance of ovarian cancer epithelial cells can be weakened. The underlying mechanism of this phenomenon may be related to the blockade of the AKT signaling pathway in ovarian cancer cells.