Axis‐Unfixed Biphenylphosphine‐Oxazoline Ligands: Design and Applications in Asymmetric Catalytic Reactions

Abstract The design and synthesis of chiral ligands plays an important role in asymmetric catalytic reactions. Over the past decades, various types of chiral phosphine‐oxazolines (PHOX ligands) have been developed and have greatly advanced the field of asymmetric catalysis. Novel chiral PHOX ligand with an axis‐unfixed biphenyl backbone, developed by our group, have shown interesting coordination behavior and excellent chiral inducing ability in various transition‐metal‐catalyzed asymmetric reactions. This personal account focuses on our developed axis‐unfixed biphenylphosphine‐oxazoline ligand (BiphPHOX), including an overview of its design and applications, which will provide inspiration for the exploration of novel ligands and related reactions.