纳米棒
材料科学
量子产额
光动力疗法
纳米技术
活性氧
产量(工程)
光致发光
体内
自组装
体外
癌症治疗
生物物理学
癌症
化学
光电子学
荧光
有机化学
生物化学
医学
物理
生物技术
量子力学
内科学
冶金
生物
作者
Ruohan Xu,Qifei Shen,Peijuan Zhang,Zhi Wang,Yanzi Xu,Lingjie Meng,Dat Nguyen Dang
标识
DOI:10.1002/adma.202402434
摘要
Abstract To enhance the phototheranostic performance, agents with high reactive oxygen species (ROS) generation, good tumor‐targeting ability, and prolonged retention are urgently needed. However, symmetric D‐A type agents usually produce spherical nanoaggregates, leading to good tumor targeting but inferior retention. Rod‐like nanoaggregates are desired to extend their retention in tumors; however, this remains a challenge. In particular, agents with dynamically changeable shapes that integrate merits of different morphologies were seldomly reported. Therefore, self‐assembled organic nanoaggregates with smart shape tunability were designed here using an asymmetric D‐A type TIBT. The photoluminescence quantum yield in solids was up to 52.24% for TIBT. TIBT also exhibited high ROS generation in corresponding nanoaggregates (TIBT‐NCs). Moreover, dynamic self‐assembly in shape changing from nanospheres to nanorods occurred in TIBT‐NCs, contributing to the enhancement of ROS quantum yield from 0.55 to 0.72. In addition, dynamic self‐assembly could be observed for both in vitro and in vivo, conferring TIBT‐NCs with strong tumor targeting and prolonged retention. Finally, efficient photodynamic therapy to inhibit tumor growth was achieved in TIBT‐NCs, with an inhibition rate of 90%. This work demonstrates that asymmetric D‐A type agents can play significant roles in forming self‐assembled organic nanoaggregates, thus showing great potential in long‐acting cancer therapy. This article is protected by copyright. All rights reserved
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