生物相容性
自愈水凝胶
伤口愈合
透明质酸
明胶
化学
单宁酸
再生(生物学)
体内
氧化应激
血管生成
抗氧化剂
活性氧
生物医学工程
生物物理学
生物化学
细胞生物学
高分子化学
有机化学
外科
解剖
癌症研究
生物技术
生物
医学
作者
Xingchen Zhao,Wenling Dai,Chenxin Liu,Mei An,Shikui Li,Likun Guo,Yujiang Fan,Xingdong Zhang
摘要
The development of advanced hydrogel dressings that integrate biocompatibility, antioxidant activity and dynamic adaptability remains critical for addressing the complex demands of modern wound management. In this study, we designed a multinetwork hydrogel (GHrCT) through synergistic strategies: A robust covalent network is constructed through photocrosslinked gelatin methacryloyl, while a secondary dynamic network formed via hydrogen bonds and electrostatic interactions is established among dopamine-modified hyaluronic acid (HD), tannic acid (TA) and recombinant collagen type III (rhCol III). Through a series of experiments, we systematically characterized key properties of the hydrogel, including its microscopic morphology, swelling behavior, rheological characteristics and mechanical strength. Biocompatibility was assessed through in vitro assays, while the wound healing efficacy was validated in vivo. In vitro experiments demonstrated that GHrCT hydrogel has interconnected porosity, excellent hemocompatibility and good cytocompatibility. Its strong antioxidant capacity (DPPH scavenging rate of 88.63%) can cope with the excessive accumulation of ROS in the wound microenvironment and reduce the damage caused by oxidative stress. Further, in vivo experiments showed that it could improve wound healing therapy by accelerating epithelial re-formation, angiogenesis and collagen deposition at full-thickness skin defects in SD rats. This study presents a strategy for functionalizing natural polymer hydrogels to enhance wound repair through the synergistic effect of scavenging ROS and promoting repair.
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