Sustainable synthesis of 1-thiol-3-alkyl bicyclo[1.1.1]pentanes via electron donor–acceptor complex photoactivation: a metal- and additive-free strategy for bioisostere design

This study demonstrates a green multicomponent reaction driven by electron donor–acceptor (EDA) complex photoactivation, enabling direct alkylation and thiolation of [1.1.1]propellane under metal- and additive-free conditions.