How to Identify Pesticide Targets?

Pesticides are essential in contemporary agriculture, as they improve crop yields and quality while safeguarding against pests. However, long-term heavy use of traditional pesticides has led to increased pest resistance, while these pesticides are often toxic and less selective, and may also have adverse effects on the environment and nontarget organisms. To solve this problem, it is important to find new targets for pesticide to develop more effective and environmentally friendly alternatives. Therefore, exploring new pesticide action targets has become one of the current research focuses. In the past years, efforts have been made to investigate possible strategies, and this work systematically summarizes and criticizes the most recently used ones. This contribution not only helps promote the research and development of new pesticides but also holds substantial implications for promoting the sustainable development of agriculture and food security.