Biomimetic dynamic nanomedicine SrHCF: Lattice self-reconstruction based on Fe2+ response to achieve synergistic “ferrous chelation-antioxidation-calcium antagonism-inflammation inhibition” quadruple treatment of CIRI

. Due to this multi-pathway therapeutic coordination mechanism, SrHCF can simultaneously inhibit neuronal ferroptosis, reduce oxidative stress and prevent calcium overload. These synergistic effects enable SrHCF to protect mitochondria and alleviate endoplasmic reticulum stress, ultimately significantly reducing neuronal death and the inflammatory storm caused by the activation of the cGAS-STING pathway of microglia. This study provides a promising paradigm of multi-target synergistic regulation for CIRI treatment.