细胞周期蛋白依赖激酶1
调节器
细胞生物学
细胞周期
生物
激酶
细胞周期蛋白依赖激酶4
细胞周期蛋白依赖性激酶3
细胞周期蛋白依赖激酶2
细胞周期蛋白
细胞生长
限制点
细胞周期蛋白B1
细胞周期蛋白依赖激酶
蛋白激酶A
细胞
生物化学
基因
作者
Giorgia Massacci,Livia Perfetto,Francesca Sacco
标识
DOI:10.1038/s41416-023-02468-8
摘要
Abstract The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival. Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key ‘cell cycle-unrelated’ biological processes. Finally, we describe how deregulation of CDK1 expression and activation has been closely associated with cancer progression and drug resistance.
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