生物
簇
细胞生物学
效应器
祖细胞
舱室(船)
电池类型
背景(考古学)
表型
干细胞
细胞
遗传学
基因
古生物学
海洋学
材料科学
地质学
复合材料
作者
Maya E. Kotas,Claire E. O’Leary,Richard M. Locksley
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2023-01-24
卷期号:18 (1): 311-335
被引量:12
标识
DOI:10.1146/annurev-pathol-042320-112212
摘要
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summarize seminal and recent findings on tuft cells, focusing on major categories of function-instigation of type 2 cytokine responses, orchestration of antimicrobial responses, and emerging roles in tissue repair-and describe tuft cell-derived molecules used to affect these functional programs. We review what is known about the development of tuft cells from epithelial progenitors under homeostatic conditions and during disease. Finally, we discuss evidence that immature, or nascent, tuft cells with potential for diverse functions are driven toward dominant effector programs by tissue- or perturbation-specific contextual cues, which may result in heterogeneous mature tuft cell phenotypes both within and between tissues.
科研通智能强力驱动
Strongly Powered by AbleSci AI