氧化应激
医学
炎症
疾病
内皮功能障碍
发病机制
生物信息学
心肌梗塞
心力衰竭
冠状动脉粥样硬化
内科学
冠状动脉疾病
生物
作者
Siarhei A. Dabravolski,Vasily N. Sukhorukov,Alexandra А. Melnichenko,Victoria A. Khotina,Alexander N. Orekhov
出处
期刊:Biomedicines
[MDPI AG]
日期:2023-07-17
卷期号:11 (7): 2010-2010
被引量:2
标识
DOI:10.3390/biomedicines11072010
摘要
Selenium is an essential trace element that is essential for various metabolic processes, protection from oxidative stress and proper functioning of the cardiovascular system. Se deficiency has long been associated with multiple cardiovascular diseases, including endemic Keshan's disease, common heart failure, coronary heart disease, myocardial infarction and atherosclerosis. Through selenoenzymes and selenoproteins, Se is involved in numerous crucial processes, such as redox homeostasis regulation, oxidative stress, calcium flux and thyroid hormone metabolism; an unbalanced Se supply may disrupt these processes. In this review, we focus on the importance of Se in cardiovascular health and provide updated information on the role of Se in specific processes involved in the development and pathogenesis of atherosclerosis (oxidative stress, inflammation, endothelial dysfunction, vascular calcification and vascular cell apoptosis). We also discuss recent randomised trials investigating Se supplementation as a potential therapeutic and preventive agent for atherosclerosis treatment.
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