Safety and efficacy of targeting the Supplementary Motor Area with double-cone deep Transcranial Magnetic Stimulation vs figure-eight coil in treatment of Obsessive-Compulsive Disorder with comorbid Major Depressive Disorder

The Supplementary Motor Area (SMA), a relatively large brain structure predominantly located along the interhemispheric fissure, is an established target for repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Obsessive-Compulsive Disorder (OCD). We investigated the feasibility, safety, and efficacy of targeting SMA using a double-cone "deep" TMS coil compared to conventional figure-eight coil for treatment of OCD with comorbid Major Depressive Disorder (MDD).