Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery

Postoperative delirium (POD) is an acute mental disorder that occurs after surgery requiring general anesthesia. In animal studies, high-mobility group box 1 (HMGB1) plays a key role in mediating postoperative neuroinflammation and may have a direct impact on POD.