光热治疗
纳米棒
黑磷
纳米点
光动力疗法
材料科学
体内
纳米医学
纳米技术
阿霉素
吸收(声学)
纳米复合材料
癌症研究
纳米颗粒
化疗
化学
光电子学
医学
生物
有机化学
复合材料
生物技术
外科
作者
Jinwen Zhu,Nan Ouyang,Ruiming Zhao,Zhenzhen Guo,Yang Jiao,Minxuan Sun,Peng Miao
标识
DOI:10.1021/acsami.3c00524
摘要
Synergetic photothermal/photodynamic/chemotherapy receives significant attention for precise in vivo cancer treatment. Despite plenty of encouraging photosensitizers explored, integrated nanoagents with multiple functions are still highly desired. In this study, novel nanocomposites coupling black phosphorus (BP) nanosheets, gold nanorods (AuNRs), carbon nanodots (CDs), and doxorubicin (Dox) are prepared. The nanoagents exhibit high antitumor activity on account of their broad light absorption, excellent catalytic ability, and significant photothermal and photodynamic effects. CDs not only emit bright fluorescence for accurate diagnosis and guiding of tumor treatment but also catalyze the generation of ROS for photodynamic therapy (PDT). The released Dox induces apoptosis of cells and increases the levels of H2O2 to promote PDT. AuNRs are the main photothermal therapy (PTT) material that converts light into heat. Moreover, BP can be used to enhance both PTT and PDT efficiencies, and the two therapy modes can be cooperatively reinforced. It is also found that the local immune microenvironment of the tumors is activated. The strategy makes good use of the features of each component. Satisfactory antitumor phenomena are well confirmed by in vitro and in vivo results. This study provides new insights into enhanced synergetic therapy, highlighting the great utility of BP-based nanoagents in the field of nanomedicine.
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