先天性淋巴细胞
实验性自身免疫性脑脊髓炎
免疫学
肠系膜淋巴结
淋巴系统
医学
脑脊髓炎
固有层
多发性硬化
免疫
生物
免疫系统
病理
上皮
作者
Milica Lazarević,Goran Stegnjaić,Bojan Jevtić,Sanja Despotović,Đurđica Ignjatović,Suzana Stanisavljević,Neda Nikolovski,Miljana Momčilović,Graeme L. Fraser,Mirjana Dimitrijević,Djordje Miljković
标识
DOI:10.1186/s12974-024-03017-7
摘要
Abstract Experimental autoimmune encephalomyelitis (EAE) induced in inbred rodents, i.e., genetically identical animals kept under identical environmental conditions, shows variable clinical outcomes. We investigated such variations of EAE in Dark Agouti rats immunized with spinal cord homogenate and identified four groups: lethal, severe, moderate, and mild, at day 28 post immunization. Higher numbers of CD4 + T cells, helper T cells type 1 (Th1) and 17 (Th17) in particular, were detected in the spinal cord of the severe group in comparison with the moderate group. In addition, increased proportion of Th1 and Th17 cells, and heightened levels of interferon (IFN)-γ and interleukin (IL)-6 were detected in the small intestine lamina propria of the severe group. A selective agonist of free fatty acid receptor type 2 (Ffar2) applied orally in the inductive phase of EAE shifted the distribution of the disease outcomes towards milder forms. This effect was paralleled with potentiation of intestinal innate lymphoid cells type 3 (ILC3) regulatory properties, and diminished Th1 and Th17 cell response in the lymph nodes draining the site of immunization. Our results suggest that different clinical outcomes in DA rats are under determinative influence of intestinal ILC3 activity during the inductive phase of EAE.
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