Inhibition of PTPN21 has antitumor effects in glioma by restraining the EGFR/PI3K/AKT pathway

胶质瘤 PI3K/AKT/mTOR通路 蛋白激酶B 基因沉默 癌症研究 表皮生长因子受体 受体酪氨酸激酶 生物 信号转导 受体 细胞生物学 生物化学 基因
作者
Xiaoqiang Li,Bochuan Liu,Xiaobing Jiang,Wenwen Gao,Bo Rong,Wei Yao,Feng-lu Wang,Haikang Zhao,Liang Zhang
出处
期刊:Toxicology and Applied Pharmacology [Elsevier BV]
卷期号:451: 116180-116180 被引量:10
标识
DOI:10.1016/j.taap.2022.116180
摘要

Protein tyrosine phosphatase non-receptor type 21 (PTPN21) has been recognised as a new tumour-associated protein that is implicated in diverse tumours. However, the correlation between PTPN21 and glioma remains unaddressed. This investigation focused on the relevance of PTPN21 in glioma. The Cancer Genome Atlas (TCGA) analysis identified PTPN21 as being up-regulated in glioma tissue. The elevation of PTP21 in glioma was validated by evaluating clinical specimen. Kaplan-Meier plot analysis revealed that a high PTPN21 level predicted poor survival rate in glioma patient. Silencing of PTPN21 produced remarkable anticancer effects in glioma cells including proliferation inhibition, cell cycle arrest, metastasis suppression and enhanced chemosensitivity. Mechanistic studies uncovered that PTPN21 contributes to mediation of the phosphatidyl-inositole-3 kinase (PI3K)/AKT pathway via the regulation of epidermal growth factor receptor (EGFR). Restraint of EGFR diminished PTPN21 overexpression-induced promoting effect on PI3K/AKT pathway. Reactivation of AKT reversed PTPN21 silencing-evoked antitumor effect. The tumorigenic potential of PTPN21-silenced glioma cells in vivo was markedly compromised. In summary, this study demonstrates that silencing of PTPN21 produces remarkable anticancer effects in glioma by restraining the EGFR/PI3K/AKT pathway.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI5应助科研通管家采纳,获得10
刚刚
共享精神应助科研通管家采纳,获得50
刚刚
英姑应助科研通管家采纳,获得10
刚刚
科研通AI5应助科研通管家采纳,获得10
刚刚
Akim应助科研通管家采纳,获得10
刚刚
QOP应助科研通管家采纳,获得10
刚刚
科研通AI6应助科研通管家采纳,获得10
1秒前
Akim应助科研通管家采纳,获得10
1秒前
tuanheqi应助科研通管家采纳,获得150
1秒前
打打应助科研通管家采纳,获得10
1秒前
脑洞疼应助科研通管家采纳,获得10
1秒前
QOP应助科研通管家采纳,获得10
1秒前
chenqiumu应助科研通管家采纳,获得20
1秒前
浮游应助科研通管家采纳,获得10
1秒前
上官若男应助科研通管家采纳,获得10
1秒前
wwyy应助科研通管家采纳,获得100
1秒前
完美世界应助感动背包采纳,获得10
2秒前
wade发布了新的文献求助10
4秒前
4秒前
5秒前
花藏影完成签到,获得积分10
6秒前
慕青应助平常毛衣采纳,获得10
8秒前
浮游应助州府十三采纳,获得10
8秒前
9秒前
10秒前
灵巧的导师完成签到,获得积分10
10秒前
shgd完成签到,获得积分10
12秒前
zwy发布了新的文献求助10
15秒前
wade完成签到,获得积分10
15秒前
18秒前
隐形曼青应助闭眼玩手机采纳,获得10
18秒前
量子星尘发布了新的文献求助10
19秒前
小蘑菇应助pingli19861002采纳,获得10
20秒前
20秒前
23秒前
飘飘玲应助刘恒宇采纳,获得10
23秒前
alooof发布了新的文献求助10
26秒前
26秒前
pcr163应助QinLi采纳,获得50
26秒前
斯文败类应助小熊同学采纳,获得30
26秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Encyclopedia of Materials: Plastics and Polymers 1000
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
Hidden Generalizations Phonological Opacity in Optimality Theory 1000
Handbook of Social and Emotional Learning, Second Edition 900
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4920227
求助须知:如何正确求助?哪些是违规求助? 4191881
关于积分的说明 13019681
捐赠科研通 3962699
什么是DOI,文献DOI怎么找? 2172183
邀请新用户注册赠送积分活动 1190075
关于科研通互助平台的介绍 1098875