先天免疫系统
免疫系统
生物
共生
肠道菌群
免疫学
寄主(生物学)
微生物学
细胞生物学
细菌
生态学
遗传学
作者
Margaret Coates,Min Jin Lee,Diana Norton,Amanda S. MacLeod
标识
DOI:10.3389/fimmu.2019.02950
摘要
The skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both commensal and pathogenic, which encompass bacteria, viruses, fungi, and parasites. The skin and intestine must maintain homeostasis with the diversity of commensal organisms present on epithelial surfaces. Here we review the current literature pertaining to epithelial barrier formation, microbial composition, and the complex regulatory mechanisms governing the interaction between the innate immune system and microbiota in the skin and intestine. We also compare and contrast the skin and intestine-two different organ systems responsible creating a protective barrier against the external environment, each of which has unique mechanisms for interaction with commensal populations and host repair.
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