免疫学
造血
免疫系统
炎症
疟疾
机制(生物学)
发病机制
癌症研究
生物
医学
干细胞
细胞生物学
认识论
哲学
作者
Na Guo,Kui Zhang,Xingchun Gao,Minghua Lv,Jing Luan,Zhifang Hu,Li Ailian,Xingchun Gou
标识
DOI:10.1016/j.retram.2020.05.003
摘要
The levels of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), a type I transmembrane glycoprotein broadly expressed on the majority of hematopoietic cells, such as T/B cells and natural killer cells, vary significantly during cell differentiation and activation. Previous studies focused mainly on the role of LAIR-1 in physiology and some pathological conditions, including autoimmune diseases. It has been shown that LAIR-1 mediates immune suppression, further resulting in uncontrolled inflammation. Furthermore, recent studies showed that LAIR-1 participates in the development of hematopoietic and non-hematopoietic tumors as well as malaria. This review summarizes the current findings on LAIR-1 in various diseases, its potential roles in pathogenesis, and provides new insight into the treatment of patients through suppression of the function of LAIR-1.
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