地图集(解剖学)
脑功能
光学切片
神经突
神经科学
断层摄影术
高分辨率
脑图谱
解剖
光学
生物
生物医学工程
计算机科学
显微镜
医学
地质学
物理
遥感
生物化学
体外
作者
Anan Li,Hui Gong,Bin Zhang,Qingdi Wang,Yan Cheng,Jingpeng Wu,Qian Liu,Shaoqun Zeng,Qingming Luo
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-12-03
卷期号:330 (6009): 1404-1408
被引量:447
标识
DOI:10.1126/science.1191776
摘要
The neuroanatomical architecture is considered to be the basis for understanding brain function and dysfunction. However, existing imaging tools have limitations for brainwide mapping of neural circuits at a mesoscale level. We developed a micro-optical sectioning tomography (MOST) system that can provide micrometer-scale tomography of a centimeter-sized whole mouse brain. Using MOST, we obtained a three-dimensional structural data set of a Golgi-stained whole mouse brain at the neurite level. The morphology and spatial locations of neurons and traces of neurites could be clearly distinguished. We found that neighboring Purkinje cells stick to each other.
科研通智能强力驱动
Strongly Powered by AbleSci AI