New Methoxy-Substituted Tritylamine Linkers for the Solid Phase Synthesis of Protected Peptide Amides

Abstract Syntheses of new methoxy-substituted tritylamine linkers in only four steps for the solid phase synthesis of peptide amides via the Fmoc/tBu strategy are described and their properties compared. Peptide amides can be cleaved under mild acidic conditions in high purity in their protected of deprotected form.