细胞周期蛋白依赖激酶
生物
细胞周期
细胞生物学
细胞分裂
限制点
细胞周期蛋白
秀丽隐杆线虫
细胞生长
CDK抑制剂
基因
遗传学
细胞
出处
期刊:Wormbook
[WormBook]
日期:2005-01-01
被引量:85
标识
DOI:10.1895/wormbook.1.28.1
摘要
Cell-division control affects many aspects of development. Caenorhabditis elegans cell-cycle genes have been identified over the past decade, including at least two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and negative regulators, and downstream targets. The balance between CDK activation and inactivation determines whether cells proceed through G1 into S phase, and from G2 to M, through regulatory mechanisms that are conserved in more complex eukaryotes. The challenge is to expand our understanding of the basic cell cycle into a comprehensive regulatory network that incorporates environmental factors and coordinates cell division with growth, differentiation and tissue formation during development. Results from several studies indicate a critical role for CKI-1, a CDK inhibitor of the Cip/Kip family, in the temporal control of cell division, potentially acting downstream of heterochronic genes and dauer regulatory pathways.
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