白粉病
生物
拟南芥
植物免疫
青梅
内吞作用
液泡
细胞生物学
效应器
植物抗病性
拟南芥
突变体
免疫
内体
植物
遗传学
免疫系统
基因
细胞
细胞内
细胞质
作者
Guangheng Wu,Simu Liu,Yaofei Zhao,Wei Wang,Zhaosheng Kong,Dingzhong Tang
出处
期刊:The Plant Cell
[Oxford University Press]
日期:2015-03-01
卷期号:27 (3): 857-873
被引量:73
标识
DOI:10.1105/tpc.114.134668
摘要
Obligate biotrophs, such as the powdery mildew pathogens, deliver effectors to the host cell and obtain nutrients from the infection site. The interface between the plant host and the biotrophic pathogen thus represents a major battleground for plant-pathogen interactions. Increasing evidence shows that cellular trafficking plays an important role in plant immunity. Here, we report that Arabidopsis thaliana ENHANCED DISEASE RESISTANCE4 (EDR4) plays a negative role in resistance to powdery mildew and that the enhanced disease resistance in edr4 mutants requires salicylic acid signaling. EDR4 mainly localizes to the plasma membrane and endosomal compartments. Genetic analyses show that EDR4 and EDR1 function in the same genetic pathway. EDR1 and EDR4 accumulate at the penetration site of powdery mildew infection, and EDR4 physically interacts with EDR1, recruiting EDR1 to the fungal penetration site. In addition, EDR4 interacts with CLATHRIN HEAVY CHAIN2 (CHC2), and edr4 mutants show reduced endocytosis rates. Taken together, our data indicate that EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 in Arabidopsis.
科研通智能强力驱动
Strongly Powered by AbleSci AI