石墨烯
万古霉素
机制(生物学)
氧化物
化学
化学工程
纳米技术
作者
He Xing,Zhou Ziyan,Han Zhuo,Yang Zeng,Xiaojie Chen,Jiacan Su
出处
期刊:ACS omega
[American Chemical Society]
日期:2019-07-17
卷期号:4 (7): 12252-12258
被引量:2
标识
DOI:10.1021/acsomega.9b00873
摘要
The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π-π stacking and hydrogen bonding. Both CGO-VAN and GO-VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO-VAN system were mainly due to the crumpled morphology.
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