수장 족저 농포증 , 건선 , 한포진 병변에서의 Interleukin-8에 대한 면역조직화학적 고찰

Background：Interleukin-8 (IL-8) is known to have an important role in the development of psoriasis. The relationship between the palmoplantar pustulosis and psoriasis is not clarified yet, but the common histologic finding, intraepidermal accumulation of neutrophils, suggests that IL-8 may have significant roles in the pathogenesis of palmoplantar pustulosis. Pompholyx showes spongiotic dermatitis and seems to have little association with IL-8 in its pathogenesis. Objective：We performed this study to elucidate the roles of IL-8 in the pathogenesis of palmoplantar pustulosis, psoriasis, and pompholyx. Methods: Immunohistochemical staining was done using frozen skin samples of 10 cases of each disease group and normal control. Results：Diffuse/strong IL-8 immunoreactivity was noted in palmoplantar pustulosis and psoriasis, whereas only faint/focal immunoreactivity was shown in normal control skin. Pompholyx showed moderate to faint immunoreactivity for IL-8. The scores of immunoreactivity in palmoplantar pustulosis and psoriasis were significantly higher than that of normal skin, but the scores of immunoreactiviy in pompholyx showed no statistically significant difference from those in palmoplantar pustulosis, psoriasis and normal control. Conclusion：Our results strongly suggest that IL-8 has significant roles in the pathogenesis of palmoplantar pustulosis as well as in psoriasis.