Mechanisms of weight regain after weight loss — the role of adipose tissue

减肥 医学 脂肪因子 肥胖 脂肪组织 脂解 内分泌学 内科学 瘦素
作者
Marleen A. van Baak,Edwin C.M. Mariman
出处
期刊:Nature Reviews Endocrinology [Nature Portfolio]
卷期号:15 (5): 274-287 被引量:157
标识
DOI:10.1038/s41574-018-0148-4
摘要

One of the biggest challenges in the management of obesity is the prevention of weight regain after successful weight loss. Weight regain after weight loss has large interindividual variation. Although many factors probably contribute to this variation, we hypothesize that variability in biological responses associated with weight loss-induced shrinking of subcutaneous adipocytes has an important role. In this Review, we show that weight loss-induced variations in cellular stress, extracellular matrix remodelling, inflammatory responses, adipokine secretion and lipolysis seem to be associated with the amount of weight that is regained after successful weight loss. Weight regain could therefore, at least in part, depend on a combination of these factors. Further research on the causality of these associations could aid the development of effective strategies to prevent weight regain after successful weight loss. In obesity management, the prevention of weight regain after weight loss is a major challenge. In this Review, the authors discuss mechanisms associated with adipose tissue that are connected to weight regain, including cellular stress, extracellular matrix remodelling and inflammation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
星辰大海应助qwer1234采纳,获得10
2秒前
学白柒发布了新的文献求助20
2秒前
2秒前
大菊发布了新的文献求助10
2秒前
张医生完成签到,获得积分10
2秒前
3秒前
冷月芳华发布了新的文献求助10
3秒前
carbonhan完成签到,获得积分10
3秒前
慕青应助Ab采纳,获得30
3秒前
干净山彤发布了新的文献求助10
4秒前
ding应助大气的天蓝采纳,获得10
6秒前
knn发布了新的文献求助10
6秒前
zzzhu发布了新的文献求助10
6秒前
6秒前
alfredwu94完成签到,获得积分10
7秒前
7秒前
7秒前
nengzou完成签到,获得积分10
7秒前
8秒前
8秒前
主旋律完成签到 ,获得积分10
9秒前
朴实的猎豹完成签到,获得积分10
9秒前
10秒前
花开富贵完成签到,获得积分10
10秒前
PG发布了新的文献求助30
11秒前
11秒前
科研通AI5应助llg采纳,获得10
11秒前
HR112发布了新的文献求助10
11秒前
11秒前
啊咧发布了新的文献求助10
11秒前
干净山彤完成签到,获得积分10
11秒前
爆米花应助迪闪闪发光采纳,获得10
12秒前
12秒前
hbc发布了新的文献求助10
13秒前
glj发布了新的文献求助10
13秒前
收声发布了新的文献求助10
13秒前
13秒前
13秒前
小二郎应助富贵小粉猪采纳,获得10
15秒前
Emiya发布了新的文献求助10
15秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3793698
求助须知:如何正确求助?哪些是违规求助? 3338599
关于积分的说明 10290546
捐赠科研通 3055010
什么是DOI,文献DOI怎么找? 1676285
邀请新用户注册赠送积分活动 804326
科研通“疑难数据库(出版商)”最低求助积分说明 761836