医学
计时型
血糖性
就寝时间
匹兹堡睡眠质量指数
糖尿病
昼夜节律
体质指数
内科学
2型糖尿病
睡眠(系统调用)
睡眠开始
胰岛素
横断面研究
内分泌学
睡眠质量
精神科
认知
病理
操作系统
失眠症
计算机科学
作者
Adriana Rusu,Dana Mihaela Ciobanu,Cornelia Bala,Anca Cerghizan,Gabriela Román
标识
DOI:10.1111/1753-0407.12867
摘要
Abstract Background Social jetlag (SJL) is a small recurrent circadian rhythm disruption and the most frequent form of circadian rhythm misalignment. The main aim of this study was to investigate the effect of SJL on glycemic control, as assessed by HbA1c, in real‐life settings. Methods In all, 115 consecutive patients with type 1 diabetes (T1D) were analyzed cross‐sectionally. Data on bedtime, sleep onset latency, and wake up time on weekdays and weekends during the previous month were collected from all participants and used to calculate SJL, chronotype, and sleep duration. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). A PSQI score > 5 was considered as an indicator of poor sleep quality. Results Patients with SJL ≥ 1 hour had significantly higher adjusted values of HbA1c than those with SJL <1 hour (8.7% vs 8.0%; P = 0.029). In unadjusted multivariate regression analysis, SJL ≥ 1 hour and poor sleep quality were significant predictors of HbA1c values, explaining 22.7% and 23.5%, respectively, of the increase in HbA1c. After adjusting for age, sex, diabetes duration, insulin dose (kg/d), insulin regimen and body mass index, only SJL ≥ 1 hour remained associated with HbA1c (β = 0.253; P = 0.026). There was no significant interaction between SJL ≥ 1 hour and poor sleep quality in either the unadjusted or adjusted models ( P interaction = 0.914). Conclusions In patients with T1D, SJL is associated with poor glycemic control, acting independently of sleep quality, sleep duration, and chronotype to exert a deleterious effect on glycemic control.
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