体外
化学
组合化学
顺铂
立体化学
药物化学
生物化学
生物
遗传学
化疗
作者
Ekaterina A. Martynova,Thomas Scattolin,Enrico Cavarzerani,Mingguo Peng,Kristof Van Hecke,Flavio Rizzolio,Steven P. Nolan
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (9): 3462-3471
被引量:8
摘要
A simple synthetic pathway to Au-NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NR1R2)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI