医学
多尿
1型糖尿病
多饮
糖尿病
糖尿病酮症酸中毒
2型糖尿病
内科学
暴发型
酮症酸中毒
格列齐特
内分泌学
胰岛素
二甲双胍
酮症
自身抗体
作者
Megumi Tachibana,Akihisa Imagawa
标识
DOI:10.1016/j.beem.2022.101657
摘要
Type 1 diabetes, in part, has been recently reported as a side effect of immune checkpoint inhibitors (ICIs). The frequency of type 1 diabetes related to ICIs is estimated to be ∼3.5%. However, type 1 diabetes related to ICIs often presents with diabetic ketoacidosis or ketosis within approximately 2 weeks after hyperglycemic symptoms, such as dry mouth, polydipsia, and polyuria, necessitating urgent diagnosis and insulin treatment. Endogenous insulin secretion is depleted within 3 weeks of the clinical onset of type 1 diabetes. Moreover, the positive rate for islet-related autoantibodies has been shown to vary from 5% to 50%, and exocrine pancreatic enzyme levels are mildly increased. Thus, the clinical course of type 1 diabetes associated with ICIs is similar to that of fulminant type 1 diabetes. In this review, we describe the clinical features of type 1 diabetes associated with ICIs.
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